発表論文

最近の論文 pick up

Transient control of lytic activity via non-equilibrium chemical reaction system

Kohei Sato, Yume Nakagawa, Miki Mori, Masahiro Takinoue, and Kazushi Kinbara

Nanoscale 2024, 16, 6442–6448, DOI: 10.1039/D3NR06626F 

原著論文

2020年以降

Transient control of lytic activity via non-equilibrium chemical reaction system
Kohei Sato, Yume Nakagawa, Miki Mori, Masahiro Takinoue, and Kazushi Kinbara*
Nanoscale 2024, 16, 6442–6448, DOI: 10.1039/D3NR06626F

Synthesis and properties of multiblock amphiphilic cyclophanes with chiral aromatic units
Ryoto Matsuda, Haruki Otake, Kohei Sato*, and Kazushi Kinbara*
Polymer Journal 2023, 55, 1225–1229, DOI:10.1038/s41428-023-00812-6

Dense and Acidic Organelle-Targeted Visualization in Living Cells: Application of Viscosity-Responsive Fluorescence Utilizing Restricted Access to Minimum Energy Conical Intersection
Junya Adachi, Haruka Oda, Toshiaki Fukushima*, Beni Lestari, Hiroshi Kimura, Hiroka Sugai, Kentaro Shiraki, Rei Hamaguchi, Kohei Sato, and Kazushi Kinbara*
Analytical Chemistry 2023, 95, 5196–5204,   (ChemRxiv 2022, preprint, DOI: 10.26434/chemrxiv-2022-p8jq4)

Sensitivity Tuning of 9,10-Di(piperazinyl)anthracene Derivatives for Amphiphilic Assemblies by pH and Side-chain Modification with Monodisperse Oligo(Ethylene Glycol)s
Junya Adachi and Kazushi Kinbara*
Chemistry Letters 2023, 52, 218–221, DOI: 10.1246/cl.230025  

Multiblock Amphiphilic Triptycene toward Bioinspired Molecular Rotor in Membrane
Wijak Yospanya*, Kohei Sato and Kazushi Kinbara*
Chemistry Letters 2022, 51, 1026–1028, DOI: 10.1246/cl.220360 

Supramolecular Mechanosensitive Potassium Channel Formed by Fluorinated Amphiphilic Cyclophane
Kohei Sato*, Ryo Sasaki, Ryoto Matsuda, Mayuko Nakagawa, Toru Ekimoto, Tsutomu Yamane, Mitsunori Ikeguchi, Kazuhito V. Tabata, Hiroyuki Noji, and Kazushi Kinbara*
Journal of the American Chemical Society 2022, 144, 11802–11809, DOI: 10.1021/jacs.2c04118   (Selected as “Supplementary Cover)

Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles
Kohei Sato*, Takahiro Muraoka and Kazushi Kinbara*
Acc. Chem. Res 2021,  54, 3700-3709, DOI: 10.1021/acs.accounts.1c00397 

Characterization of a novel type of carbonic anhydrase that acts without metal cofactors
Yoshihisa Hirakawa*, Miki Senda, Kodai Fukuda, Hong Yang Yu, Masaki Ishida, Masafumi Taira, Kazushi Kinbara and Toshiya Senda*
BMC Biology 2021, 19, 105, DOI: 10.1186/s12915-021-01039-8 

Properties of Imidazolinium-containing Multiblock Amphiphile in Lipid Bilayer Membranes
Miki Mori and Kazushi Kinbara*
Journal of Photopolymer Science and Technology 2021, 34, 161–165, DOI: 10.2494/photopolymer.34.161 

Calcium-induced reversible assembly of phosphorylated amphiphile within lipid bilayer membranes
Yusuke Shimizu, Kohei Sato*, and Kazushi Kinbara*
Chemical Communications 2021, 57, 4106–4109, DOI:10.1039/D1CC01111A  (Selected as “Front Cover)

Synthetic Ion Channel Formed by Multiblock Amphiphile with Anisotropic Dual Stimuli-Responsiveness
Ryo Sasaki, Kohei Sato*, Kazuhito Tabata, Hiroyuki Noji, and Kazushi Kinbara*
Journal of the American Chemical Society 2021, 143, 1348–1355, DOI:10.1021/jacs.0c09470 

Imidazolinium‐based Multiblock Amphiphile as Transmembrane Anion Transporter
Miki Mori, Kohei Sato, Toru Ekimoto, Shinichi Okumura, Mitsunori Ikeguchi, Kazuhito V Tabata, Hiroyuki Noji, and Kazushi Kinbara*
Chemistry – An Asian Journal 2021, 16, 147–157, DOI:10.1002/asia.202001106  (Selected as “Front Cover)

Thermo-driven self-assembly of a PEG-containing amphiphile in a bilayer membrane
Rui Li, Takahiro Muraoka, and Kazushi Kinbara*
RSC Advances 2020, 10, 25758–25762, DOI: 10.1039/D0RA03920A 

A synthetic ion channel with anisotropic ligand response
Takahiro Muraoka*, Daiki Noguchi, Rinshi S. Kasai, Kohei Sato, Ryo Sasaki, Kazuhito V. Tabata, Toru Ekimoto, Mitsunori Ikeguchi, Kiyoto Kamagata, Norihisa Hoshino, Hiroyuki Noji, Tomoyuki Akutagawa, Kazuaki Ichimura, and Kazushi Kinbara*
Nature Communications 2020, 11, 2924, DOI:10.1038/s41467-020-16770-z 

Reversible formation of multiple stimuli-responsive polymeric materials through processing control of trifunctional amphiphilic molecule
Takahiro Muraoka*, Hidetaka Honda, Kota Nabeya, and Kazushi Kinbara*
Chemical Communications 2020, 56, 7881–7884, DOI: 10.1039/D0CC02716B 

Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes
Ryo Sasaki, Kohei Sato*, and Kazushi Kinbara*
ChemistryOpen 2020, 9, 301–303, DOI:10.1002/open.201900374 

New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures
Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Shigenori Tanaka, Kazushi Kinbara, and Naoki Sugimoto*
Molecules 2020, 25, 705, DOI:10.3390/molecules25030705 

2010-2019

Development of an Engineered Photoactive Yellow Protein as a Cross‐Linking Junction for Construction of Photoresponsive Protein‐Polymer Conjugates
Mihoko Ui, Yusuke Miyauchi, Masataka Inoue, Makoto Murakami, Yasuyuki Araki, Takehiko Wada, and Kazushi Kinbara*
ChemPhotoChem 2019, 3, 356–360, DOI: 10.1002/cptc.201900024 

Heat-Triggered Crystallization of Liquid Crystalline Macrocycles Allowing for Conductance Switching through Hysteretic Thermal Phase Transitions
Takahiro Muraoka, Tatsuya Shima, Takashi Kajitani, Norihisa Hoshino, Estelle Morvan, Axelle Grélard, Erick J. Dufourc, Takanori Fukushima, Tomoyuki Akutagawa, Kota Nabeya, and Kazushi Kinbara*
Chem. Asian J. 2019, 14, 141–148, DOI:10.1002/asia.201801372  

Localization of transmembrane multiblock amphiphilic molecules in phase-separated vesicles
Kazushi Kinbara*, Kaori Umetsu, Hiroki Sonobe, Takahiro Muraoka, Naofumi Shimokawa, and  Masahiro Takagi
Faraday Discuss. 2018, 209, 315–328, DOI: 10.1039/C8FD00022K 

Thermal and optical properties of multiblock macrocycles with hysteretic polymorphic transition
Kota Nabeya, Takahiro Muraoka*, Norihisa Hoshino, Miho Aizawa, Takashi Kajitani, Tomoyuki Akutagawa, Atsushi Shishido, Takanori Fukushima,and Kazushi Kinbara*
Mater. Chem. Front. 2018, 2, 969–974, DOI: 10.1039/C7QM00621G 

Enzymatically cleavable traceless biotin tags for protein PEGylation and purification
Adam M. Wawro, Yusuke Aoki, Takahiro Muraoka*, Kouhei Tsumoto and Kazushi Kinbara*
Chem. Commun. 2018, 54, 1913–1916,  DOI: 10.1039/C7CC05814D 

Multifarious Polymorphism of a Multiblock Amphiphilic Macrocycle Bearing Thermally Responsive Polyether Segment
Takahiro Muraoka*, Tatsuya Shima, and Kazushi Kinbara*
ACS Omega 2018, 3, 414–418, , DOI: 10.1021/acsomega.7b01737 

Mechano-Sensitive Synthetic Ion Channels
Takahiro Muraoka*, Kaori Umetsu, Kazuhito V. Tabata, Tsutomu Hamada, Hiroyuki Noji, Takashi Yamashita, and Kazushi Kinbara*
J. Am. Chem. Soc. 2017, 139, 18016–18023, DOI: 10.1021/jacs.7b09515 

Thermally-induced lateral assembly of PEG-containing amphiphile triggering vesicle budding
Rui Li, Takahiro Muraoka*, and Kazushi Kinbara*
Chem. Commun. 2017, 53, 11662–11665,  DOI: 10.1039/C7CC06489F 

Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH–π interactions
Hisae Tateishi-Karimata* , Tatsuya Ohyama, Takahiro Muraoka, Peter Podbevsek, Adam M. Wawro, Shigenori Tanaka, Shu-ichi Nakano, Kazushi Kinbara, Janez Plavec, and Naoki Sugimoto*
Nucleic Acids Res. 2017, 45, 7021–7030, DOI: 10.1093/nar/gkx299 

Multigram chromatography-free synthesis of octa(ethylene glycol) p-toluenesulfonate
Adam M. Wawro, Takahiro Muraoka, Maho Kato, and Kazushi Kinbara*
Org. Chem. Front. 2016, 3, 1524–1534, DOI: 10.1039/C6QO00398B 

G-quadruplexes with Tetraethylene Glycol-modified Deoxythymidines Are Resistant to Nucleases and Inhibit HIV-1 Reverse Transcriptase
Hisae Tateishi-Karimata, Takahiro Muraoka, Kazushi Kinbara, and Naoki Sugimoto*
ChemBioChem 2016, 17, 1399–1402, DOI: 10.1002/cbic.201600162 

Contrasting Topological Effect of PEG-containing Amphiphiles to Natural Lipids on Stability of Vesicles
Rui Li, Takahiro Muraoka*, and Kazushi Kinbara*
Langmuir  2016, 32, 4546–4553, DOI: 10.1021/acs.langmuir.6b00713

Chromatography-Free Synthesis of Monodisperse Oligo(ethylene glycol) Mono-p-toluenesulfonates and Quantitative Analysis of Oligomer Purity
Adam. M. Wawro, Takahiro Muraoka, and Kazushi Kinbara*
Polym. Chem. 2016, 7, 2389–2394, DOI: 10.1039/C6PY00127K 

Synthesis and Thermal Responses of Polygonal Poly(ethylene glycol) Analogues
Shunichi Kawasaki, Takahiro Muraoka, Tsutomu Hamada, Kazuki Shigyou, Fumi Nagatsugi and Kazushi Kinbara
Chem. Asian J. 2016, 11, 1028–1035 (selected as a Very Important Paper (VIP), Top Cover, Highlighted in ChemistryViews),  DOI: 10.1002/asia.201501381

Protein Stabilization by an Amphiphilic Short Monodisperse Oligo(ethylene glycol)
Nabanita Sadhukhan, Takahiro Muraoka, Mihoko Ui, Satoru Nagatoishi, Kouhei Tsumoto, and Kazushi Kinbara*
Chem. Commun. 2015, 51, 8457–8460.

Reversible Ion Transportation Switch by a Ligand-Gated Synthetic Supramolecular Ion Channel
Takahiro Muraoka*, Takahiro Endo, Kazuhito V. Tabata, Hiroyuki Noji, Satoru Nagatoishi, Kouhei Tsumoto, Rui Li and Kazushi Kinbara*
J. Am. Chem. Soc. 2014, 136, 15584–15595, DOI: 10.1021/ja5070312 

Grafting Synthetic Transmembrane Units to the Engineered Low-Toxicity alpha-Hemolysin to Restore Its Hemolytic Activity
Mihoko Ui, Kousuke Harima, Toshiaki Takei, Kouhei Tsumoto, Kazuhito V. Tabata, Hiroyuki Noji, Sumire Endo, Kimio Akiyama, Takahiro Muraoka, and Kazushi Kinbara*
Mol. BioSyst. 2014, 10, 3199–3206, DOI: 10.1039/C4MB00405A 

Light-Triggered Vesicle Formation: Important Factors for Generation of Vesicles and Possible Applications
Tatsuya Shima, Takahiro Muraoka, Kazuhito V. Tabata, Hiroyuki Noji and Kazushi Kinbara
Pure Appl. Chem. 2014, 86, 1259–1267, DOI: 10.1515/pac-2014-0604 

Single-Cell E. coli Response to an Instantaneously Applied Chemotactic Signal
Takashi Sagawa, Yu Kikuchi, Yuichi Inoue, Hiroto Takahashi, Takahiro Muraoka, Kazushi Kinbara, Akihiko Ishijima and Hajime Fukuoka*
Biophys. J. 2014, 107, 730–739, DOI: 10.1016/j.bpj.2014.06.017 

Thermodriven Micrometer-Scale Aqueous-Phase Separation of Amphiphilic Oligoethylene Glycol Analogues
Shunichi Kawasaki, Takahiro Muraoka, Haruki Obara, Takerou Ishii, Tsutomu Hamada and Kazushi Kinbara
Chem. Asian J. 2014, 9, 2778–2788, DOI: 10.1002/asia.201402134  (Selected as the Back Cover).

Development of Self-Assembling Alternating Amphiphilic Compounds
Takahiro Muraoka, Nabanita Sadhukhan, Rui Li and Kazushi Kinbara
J. Photopolym. Sci. Tec. 2014, 27, 557–560, DOI: 10.2494/photopolymer.27.557 

Micrometer-Size Vesicle Formation Triggered by UV Light
Tatsuya Shima, Takahiro Muraoka, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Hajime Fukuoka, Yuichi Inoue, Takashi Sagawa, Akihiko Ishijima, Yuki Omata, Takashi Yamashita and Kazushi Kinbara*
Langmuir 2014, 30, 7289–7295, DOI: 10.1021/la5008022 

Thermally Driven Polymorphic Transition Prompting a Naked-Eye-Detectable Bending and Straightening Motion of Single Crystals
Tatsuya Shima, Takahiro Muraoka, Norihisa Hoshino, Tomoyuki Akutagawa, Yuka Kobayashi and Kazushi Kinbara*
Angew. Chem. Int. Ed. 2014, 53, 7173–7178, DOI: 10.1002/anie.201402560 

Thermoresponsive Self-assembly and Conformational Changes of Amphiphilic Monodisperse Short Poly(ethylene glycol)s in Water
Nabanita Sadhukhan, Takahiro Muraoka, Daisuke Abe, Yuji Sasanuma, Dwiky Rendra Graha Subekti and Kazushi Kinbara*
Chem. Lett. 2014, 43, 1055–1057, DOI: 10.1246/cl.140241 

Transetherification on Polyols by Intra- and Intermolecular Nucleophilic Substitutions
Takahiro Muraoka, Kota Adachi, Rainy Chowdhury and Kazushi Kinbara*
PLoS ONE 2014, 9, e91912, DOI: 10.1371/journal.pone.0091912 

Thermal-Aggregation Suppression of Proteins by a Structured PEG Analogue: Importance of Denaturation Temperature for Effective Aggregation Suppression
Takahiro Muraoka, Nabanita Sadhukhan, Mihoko Ui, Shunichi Kawasaki, Enrikko Hazemi, Kota Adachi, and Kazushi Kinbara*
Biochem. Eng. J. 2014, 86C, 41–48, DOI: 10.1016/j.bej.2014.03.001 

Biomolecular Robotics for Chemomechanically Driven Guest Delivery Duelled by Intracellular ATP
Shuvendu Biswas, Kazushi Kinbara, Tatsuya Niwa, Hideki Taguchi, Noriyuki Ishii, Sumiyo Watanabe, Kanjiro Miyata, Kazunori Kataoka and Takuzo Aida*
Nature Chem. 2013, 5, 613–620, DOI: 10.1038/nchem.1681 

A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation
Takahiro Muraoka*, Kota Adachi, Mihoko Ui, Shunichi Kawasaki, Nabanita Sadhukhan, Haruki Obara, Hidehito Tochio, Masahiro Shirakawa, and Kazushi Kinbara*
Angew. Chem. Int. Ed. 2013, 52, 2430–2434, DOI: 10.1002/anie.201206563  [Selected as a “Very Important Paper (VIP)” and a Back Cover, Highlighted in Wiley-JAPAN Science Cafe].

Ion Permeation by a Folded Multiblock Amphiphilic Oligomer Achieved by Hierarchical Construction of Self-Assembled Nanopores
Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazuhito V. Tabata, Hiroyuki Noji, and Kazushi Kinbara*
J. Am. Chem. Soc. 2012, 134, 19788–19794, DOI: 10.1021/ja308342g

Amplification of Light-induced Molecular-Shape Change by Supramolecular Machines
Mihoko Ui, Yoshikazu Tanaka, and Kazushi Kinbara*
J. Photopolym. Sci. Technol. 2012, 25, 655-658, DOI: 10.2494/photopolymer.25.655 

Application of Photoactive Yellow Protein as a Photoresponsive Module for Controlling Hemolytic Activity of Staphylococcal a-Hemolysin
Mihoko Ui, Yoshikazu Tanaka, Yasuyuki Araki, Takehiko Wada, Toshiaki Takei, Kouhei Tsumoto, and Kazushi Kinbara*
Chem. Commun. 2012, 48, 4737-4739, DOI: 10.1039/C2CC18118E 

Controlling Volume Shrinkage in Soft Lithography through Heat-Induced Cross-Linking of Patterned Nanofibers
Yasunao Miyamura, Chiyoung Park, Kazushi Kinbara, Frank A. Leibfarth, Craig J. Hawker, and Takuzo Aida
J. Am. Chem. Soc. 2011, 133, 2840–2843, DOI: 10.1021/ja110901h 

Mimicking Multipass Transmembrane Proteins: Synthesis, Assembly and Folding of Alternating Amphiphilic Multiblock Molecules in Liposomal Membranes
Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, and Kazushi Kinbara*
Chem. Commun. 2011, 47, 194–196, DOI: 10.1039/C0CC02420A  [Selected as a Hot Article, Emerging Investigators Issue]

Oligo(4-aminopiperidine-4-carboxylic acid): An Unusual Basic Oligopeptide with an Acid–Induced Helical Conformation
Joon-il Cho, Masahiro Tanaka, Sota Sato, Kazushi Kinbara, and Takuzo Aida*
J. Am. Chem. Soc. 2010, 132, 13176–13178, DOI: 10.1021/ja106118w 

Self-Repair of a One-Dimensional Molecular Assembly in Mesoporous Silica by a Nanoscopic Template Effect
Hendrik O. Lintang, Kazushi Kinbara, Kenichi Tanaka, Takashi Yamashita, and Takuzo Aida
Angew. Chem. Int. Ed. 2010, 49, 4241–4245, DOI: 10.1002/anie.200906578 

Adhesion Effects of a Guanidinium Ion Appended Dendritic “Molecular Glue” on the ATP-Driven Sliding Motion of Actomyosin
Kou Okuro, Kazushi Kinbara*, Kuniaki Takeda, Yuichi Inoue, Akihiko Ishijima, and Takuzo Aida
Angew. Chem. Int. Ed. 2010, 49, 3030–3033, DOI: 10.1002/anie.200906139 

Image Analysis of alpha/beta-Tubulin Rings in Two-Dimensional Crystalline Arrays of Periodic Mesporous Nanostructures
Noriyuki Ishii*, Kou Okuro, Kazushi Kinbara, and Takuzo Aida*
J. Biochem. 2010, 147, 555–563, DOI: 10.1093/jb/mvp201 

Shape-Directed Assembly of a “Macromolecular Barb” into Nanofibers:Stereospecific Cyclopolymerization of Isopropylidene Diallylmalonate
Yasunao Miyamura, Kazushi Kinbara, Yohei Yamamoto, Vakayil K. Praveen,
Kenichi Kato, Masaki Takata, Atsushi Takano, Yushu Matsushita, Eunji
Lee, Myongsoo Lee, and Takuzo Aida
J. Am. Chem. Soc. 2010, 132, 3292–3294, DOI: 10.1021/ja910901e 

High-Water-Content Mouldable Hydrogels by Mixing Clay and a Dendritic Molecular Binder
Qigang Wang, Justin L. Mynar*, Masaru Yoshida, Eunji Lee, Myongsoo Lee, Kou Okuro, Kazushi Kinbara, and Takuzo Aida*
Nature 2010, 463, 339–343, DOI: 10.1038/nature08693 

-2009

A Tubular Biocontainer: Metal Ion–Induced 1D Assembly of a Molecularly Engineered Chaperonin
Shuvendu Biswas, Kazushi Kinbara*, Nobuhiro Oya, Noriyuki Ishii, Hideki Taguchi, and Takuzo Aida*
J. Am. Chem. Soc. 2009, 131, 7556–7557, DOI: 10.1021/ja902696q 

Template Sol-Gel Synthesis of Mesostructured Silica Composites Using Metal Complexes Bearing Amphiphilic Side Chains: Immobilization of a Polymeric Pt Complex Formed by a Metallophilic Interaction
Wataru Otani, Kazushi Kinbara, and Takuzo Aida*
Faraday Discuss. 2009, 143, 335–343, DOI: 10.1039/B904896K 

Molecular Glues Carrying Multiple Guanidinium Ion Pendants via an Oligoether Spacer: Stabilization of Microtubules against Depolymerization
Kou Okuro, Kazushi Kinbara, Kouhei Tsumoto, Noriyuki Ishii, and Takuzo Aida
J. Am. Chem. Soc. 2009, 131, 1626–1627, DOI: 10.1021/ja800491v 

Toward Long-Distance Mechanical Communication: Studies on a Ternary Complex Interconnected by a Bridging Rotary Module
Hiroyuki Kai, Shinji Nara, Kazushi Kinbara, and Takuzo Aida
J. Am. Chem. Soc. 2008, 130, 6725–6727, DOI: 10.1021/ja801646b 

Toward Autonomously Operating Molecular Machines Driven by Transition-Metal Catalyst
Kenichi Tanaka and Kazushi Kinbara
Mol. BioSyst. 2008, 4, 512–514, DOI: 10.1039/B801621F  [Emerging Investigators Issue, Highlighted in Chemical Science.]

Reversible Operation of Chiral Molecular Scissors by Redox and UV Light
Takahiro Muraoka, Kazushi Kinbara*, and Takuzo Aida*
Chem. Commun. 2007, 1441–1443, DOI: 10.1039/B618248H 

Crystallographic and Chiroptical Studies on Tetraarylferrocenes for Use as Chiral Rotary Modules for Molecular Machines
Takahiro Muraoka, Kazushi Kinbara*, Atsushi Wakamiya, Shigehiro Yamaguchi, and Takuzo Aida*
Chem.–Eur. J. 2007, 13, 1724–1730, DOI: 10.1002/chem.200601098 

Catalysis of a Peptidic Micellar Assembly Covalently Immobilized within Mesoporous Silica Channels: Importance of Amphiphilic Spatial Design
Wataru Otani, Kazushi Kinbara*, Qingmin Zhang, Katsuhiko Ariga, and Takuzo Aida*
Chem.–Eur. J. 2007, 13, 1731–1736, DOI: 10.1002/chem.200601099 

A Self-Locking Molecule Operative with a Photoresponsive Key
Takahiro Muraoka, Kazushi Kinbara, and Takuzo Aida
J. Am. Chem. Soc. 2006, 128, 11600–11605.

Mechanical Twisting of a Guest by a Photoresponsive Host
Takahiro Muraoka, Kazushi Kinbara*, and Takuzo Aida*
Nature 2006, 440, 512–515, DOI: 10.1038/nature04635 [Highlighted in Angewandte Chemie, C&EN, Nanotechweb.org, Newscientist and Photonics.com.]

“Hermaphroditic Chirality” of a D2-Symmetric Saddle-Shaped Porphyrin in Multicomponent Spontaneous Optical Resolution: Inclusion Cocrystals with Double-Helical Porphyrin Arrays
Yukitami Mizuno, Md. Akhtarul Alam, Akihiko Tsuda, Kazushi Kinbara, Kentaro Yamaguchi, and Takuzo Aida*
Angew. Chem. Int. Ed. 2006, 45, 3786–3790, DOI: 10.1002/anie.200503054 

Semibiological Molecular Machine with an Implemented “AND” Logic Gate for Regulation of Protein Folding
Shinichi Muramatsu, Kazushi Kinbara*, Hideki Taguchi, Noriyuki Ishii, and Takuzo Aida*
J. Am. Chem. Soc. 2006, 128, 3764–3769, DOI: 10.1021/ja057604t 

Synthesis, Absolute Configuration, and Application of Enantiopure trans-1-Aminobenz[f]indan-2-ol
Yuka Kobayashi, Kazushi Kinbara, Masaaki Sato, and Kazuhiko Saigo*
Chirality 2005, 17, 108–112, DOI: 10.1002/chir.20101 

Rational Design of CH–pi Interaction Sites in a Basic Resolving Agent
Yuka Kobayashi, Toshie Kurasawa, Kazushi Kinbara, and Kazuhiko Saigo*
J. Org. Chem. 2004, 69, 7436–7441, DOI: 10.1021/jo049154d 

Chaperonin-Mediated Stabilization and ATP-Triggered Release of Semiconductor Nanoparticles
Daisuke Ishii, Kazushi Kinbara, Yasuhiro Ishida, Noriyuki Ishii, Mina Okochi, Masafumi Yohda, and Takuzo Aida*
Nature 2003, 423, 628–632, DOI: 10.1038/nature01663 [Highlighted in Nature, C&EN, TRNmag.com, and Nanotechweb.org.]

Light-Driven Open-Close Motion of Chiral Molecular Scissors
Takahiro Muraoka, Kazushi Kinbara, Yuka Kobayashi, and Takuzo Aida
J. Am. Chem. Soc. 2003, 125, 5612–5613, DOI: 10.1021/ja034994f  [Highlighted in Newscientist.]

Synthesis and Structure of Macrocyclic Bis(hydroxynaphthoic amide)s Connected by an Achiral or Chiral Diamine
Hiroaki Yoshida, Kazuhisa Hiratani, Tamako Ogihara, Yuka Kobayashi, Kazushi Kinbara, and Kazuhiko Saigo
J. Org. Chem. 2003, 68, 5812–5818, DOI: 10.1021/jo0340298 

Chiral Discrimination of 2-Arylalkanoic Acids by (1S,2S)-1-Aminoindan-2-ol and (1S,2S)-2-Aminoindan-1-ol: Correlation of the Relative Configuration of the Amino and Hydroxy Groups with the Pattern of a Supramolecular Hydrogen-Bond Network in the Less-Soluble Diastereomeric Salt
Kazushi Kinbara, Yoshiyuki Katsumata, and Kazuhiko Saigo
Chirality 2003, 15, 564–570, DOI: 10.1002/chir.10202 

Regio- and Stereoselective Synthesis of a trans-4-[60]Fullerenobisacetic Acid Derivative by a Tether-Directed Biscyclopropanation: A Diacid Component Applicable for the Synthesis of Regio- and Stereo-regular [60]Fullerene Pearl-Necklace Polyamides
Tetsuo Hino, Masahiro Hamada, Kazushi Kinbara, and Kazuhiko Saigo*
Chem. Lett. 2002, 31, 728–729, DOI: 10.1246/cl.2002.728 

Enantiopure trans- and cis-3-Aminoindan-1-ols: Preparation and Application as Novel Basic Resolving Agents
Kazushi Kinbara, Yoshiyuki Katsumata, and Kazuhiko Saigo*
Chem. Lett. 2002, 31, 266–267, DOI: 10.1246/cl.2002.266 

Probability of Spontaneously Resolvable Conglomerates for Racemic Acid/Racemic Amine Salts Predicted on the Basis of the Results of Diastereomeric Resolutions
Kazushi Kinbara, Yoshiyuki Tagawa, and Kazuhiko Saigo
Tetrahedron: Asymmetry 2001, 12, 2927–2930, DOI: 10.1016/S0957-4166(01)00527-4 

Tether-Linked [60]Fullerene-Donor Dyads
Jian-Yu Zheng, Shuichi Noguchi, Kenjo Miyauchi, Masahiro Hamada, Kazushi Kinbara, and Kazuhiko Saigo*
Fullerene Sci. Tech. 2001, 9, 467–475, DOI: 10.1081/FST-100107149 

Synthesis and Transformation of a Novel Methano[60]fullerene Having a Formyl Group
Masahiro Hamada, Tetsuo Hino, Kazushi Kinbara, and Kazuhiko Saigo*
Tetrahedron Lett. 2001, 42, 5069–5071, DOI: 10.1016/S0040-4039(01)00944-3 

Synthesis of Methano[60]fullerene Derivatives: the Fluoride Ion-Mediated Reaction of [60]Fullerene with Silylated Nucleophiles
Tetsuo Hino, Kazushi Kinbara, and Kazuhiko Saigo*
Tetrahedron Lett. 2001, 42, 5065–5067, DOI: 10.1016/S0040-4039(01)00943-1 

Cyclic Dimers of Metalloporphyrins as Tunable Hosts for Fullerenes: A Remarkable Effect of Rhodium(III)
Jian-Yu Zheng, Kentaro Tashiro, Yusuke Hirabayashi, Kazushi Kinbara, Kazuhiko Saigo*, Takuzo Aida*, Shigeru Sakamoto, and Kentaro Yamaguchi
Angew. Chem. Int. Ed. 2001, 40, 1857–1861, DOI: 10.1002/1521-3773(20010518)40:10<1857::AID-ANIE1857>3.0.CO;2-Y

Chemical Modification of Amide-Based Catenanes and Rotaxanes II. Synthesis of Tertiary Amine [2]Catenanes and [2] Rotaxanes via N-Methylation Followed by Borane Reduction of Secondary Amide [2]Catenanes and [2]Rotaxanes and Mobility of Their Components
Nobuhiro Watanabe, Yoshio Furusho, Nobuhiro Kihara, Toshikazu Takata, Kazushi Kinbara*, and Kazuhiko Saigo
Bull. Chem. Soc. Jpn. 2001, 74, 149–155, DOI: 10.1246/bcsj.74.149 

Azidoacetamide, a Neutral Small Organic Azide
Mieko Kumasaki*, Kazushi Kinbara, Yuji Wada, Mitsuru Arai, and Masamitsu Tamura
Acta Crystallogr. Sect. E 2001, 57, o6–o8, DOI: 10.1107/S160053680001850X 

Molecular Design of a Novel Dendrimer Porphyrin for Supramolecular Fullerene/Dendrimer Hybridization
Tomoko Nishioka, Kentaro Tashiro, Takuzo Aida*, Jian-Yu Zheng, Kazushi Kinbara, Kazuhiko Saigo*, Shigeru Sakamoto, and Kentaro Yamaguchi
Macromolecules 2000, 33, 9182–9184, DOI: 10.1021/ma001384g 

Effect of a Substituent on an Aromatic Group in Diastereomeric Resolution
Kazushi Kinbara, Koji Oishi, Yoshiko Harada, and Kazuhiko Saigo*
Tetrahedron 2000, 56, 6651–6655, DOI: 10.1016/S0040-4020(00)00472-5 

A High-Performance, Tailor-Made Resolving Agent: Remarkable Enhancement of Resolution Ability by Introducing a Naphthyl Group to the Fundamental Skeleton
Kazushi Kinbara, Yoshiko Harada, and Kazuhiko Saigo*
J. Chem. Soc., Perkin Trans. 2 2000, 2000, 1339–1347, DOI: 10.1039/B000903M 

Chiral Discrimination of 2-Arylalkanoic Acids by (1S,2R)-1-Aminoindan-2-ol through the Formation of a Consistent Columnar Supramolecular Hydrogen-Bond Network
Kazushi Kinbara, Yuka Kobayashi, and Kazuhiko Saigo*
J. Chem. Soc., Perkin Trans. 2 1999, 2000, 111–119, DOI: 10.1039/A905566E 

A Cyclic Dimer of Metalloporphyrin Forms a Highly Stable Inclusion Complex with C60
Kentaro Tashiro, Takuzo Aida*, Jiang-Yu Zheng, Kazushi Kinbara, Kazuhiko Saigo*, Shigeru Sakamoto, and Kentaro Yamaguchi
J. Am. Chem. Soc. 1999, 121, 9477–9478, DOI: 10.1021/ja992416m 

Synthesis and Structure of [2]Catenated Tertiary Ocatamide and Octamine
Nobuhiro Watanabe, Yoshio Furusho, Nobuhiro Kihara, Toshikazu Takata, Kazushi Kinbara*, and Kazuhiko Saigo
Chem. Lett. 1999, 28, 915–916, DOI: 10.1246/cl.1999.915 

A Novel Reaction of [60]Fullerene. A Formal [2+2] Cycloaddition with Aryloxy- and Alkoxyketenes
Satoshi Matsui, Kazushi Kinbara, and Kazuhiko Saigo*
Tetrahedron Lett. 1999, 40, 899–902, DOI: 10.1016/S0040-4039(98)02477-0 

Synthesis and Properties of Polyamides with [60]Fullerene in the Main Chain
Masaki Ozawa, Jing Li, Kentaro Nakahara, Lixin Xiao, Hiroharu Sugawara, Koichi Kitazawa*, Kazushi Kinbara, and Kazuhiko Saigo*
J. Polym. Sci., Part A: Polym. Chem. 1998, 36, 3139–3146, DOI: 10.1002/(SICI)1099-0518(199812)36:17<3139::AID-POLA16>3.0.CO;2-W

Reciprocal Resolution of 1-(4-Methylphenyl)ethylamine and 2-Hydroxy-4-phenylbutyric Acid, and Habit Modification of a Less-Soluble Diastereomeric Salt with a Chiral Additive
Kenichi Sakai, Shinichi Yoshida, Yukihiko Hashimoto, Kazushi Kinbara, Kazuhiko Saigo, and Hiroyuki Nohira
Enantiomer 1998, 3, 23–35.

Systematic Study of Chiral Discrimination upon Crystallisation 2: Chiral Discrimination of 2-Arylalkanoic Acids by (1R,2S)-2-Amino-1,2-diphenylethanol
Kazushi Kinbara, Yuka Kobayashi, and Kazuhiko Saigo*
J. Chem. Soc., Perkin Trans. 2 1998, 1998, 1767–1775, DOI: 10.1039/A802583E 

(2-Naphthyl)glycolic Acid: A Tailored Resolving Agent for p-Substituted 1-Arylalkylamines
Kazushi Kinbara, Yoshiko Harada, and Kazuhiko Saigo*
Tetrahedron: Asymmetry 1998, 9, 2219–2222, DOI: 10.1016/S0957-4166(98)00242-0 

Novel Copolyamides Containing [60]Fullerene in the Main Chain
Jing Li, Toshiyuki Yoshizawa, Mari Ikuta, Masaki Ozawa, Kentaro Nakahara, Tetsuya Hasegawa, Koichi Kitazawa*, Minoru Hayashi, Kazushi Kinbara, Masao Nohara, and Kazuhiko Saigo*
Chem. Lett. 1997, 26, 1037–1038, DOI: 10.1246/cl.1997.1037 

Formation of Ketones from Alkyl Nitrites in the Solid State
Kazushi Kinbara, Hiroshi Takezaki, Akiyoshi Kai, and Kazuhiko Saigo*
Chem. Lett. 1996, 25, 217–218, DOI: 10.1246/cl.1996.217 

Photochemical EZ-Isomerization of alpha,beta-Unsaturated Amides and Thioamides in the Solid State
Kazushi Kinbara and Kazuhiko Saigo*
Bull. Chem. Soc. Jpn. 1996, 69, 779–784, DOI: 10.1246/bcsj.69.779 

Design of Resolving Reagents: p-Substituted Mandelic Acids as Resolving Reagents for 1-Arylalkylamines
Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto, Hiroyuki Nohira, and Kazuhiko Saigo*
Tetrahedron: Asymmetry 1996, 7, 1539–1542, DOI: 10.1016/0957-4166(96)00175-9 

Photoisomerization of Ammonium alpha,beta-Unsaturated Carboxylates in the Solid State: Effect of the Hydrogen-Bonding Network on the Reactivity
Kazushi Kinbara, Akiyoshi Kai, Yasunari Maekawa, Yukihiko Hashimoto, Shoji Naruse, Masaki Hasegawa, and Kazuhiko Saigo*
J. Chem. Soc., Perkin Trans. 2 1996, 247–253, DOI: 10.1039/P29960000247

Chiral Discrimination upon Crystallisation of the Diastereomeric Salts of 1-Arylethylamines with Mandelic Acid or p-Methoxymandelic Acid: Interpretation of the Resolution Efficiencies on the Basis of the Crystal Structures
Kazushi Kinbara, Kenichi Sakai, Yukihiko Hashimoto, Hiroyuki Nohira, and Kazuhiko Saigo*
J. Chem. Soc., Perkin Trans. 2 1996, 2615–2622, DOI: 10.1039/P29960002615

Crystal Structures of the Salts of Chiral Primary Amines with Achiral Carboxylic Acids: Recognition of the Commonly-Occuring Supramolecular Assemblies of Hydrogen-Bond Networks and Their Role in the Formation of Conglomerate
Kazushi Kinbara, Yukihiko Hashimoto, Makoto Sukegawa, Hiroyuki Nohira, and Kazuhiko Saigo*
J. Am. Chem. Soc. 1996, 118, 3441–3449, DOI: 10.1021/ja9539960 

Formation of Topochemically Photoreactive Mixed Crystal by Grinding and Its Mechanistic Interpretation
Kazushi Kinbara, Yutaka Adegawa, Kazuhiko Saigo*, and Masaki Hasegawa*
Bull. Chem. Soc. Jpn. 1993, 66, 1204–1210, 1204–1210, DOI: 10.1246/bcsj.66.1204 

Optical Resolution of 1-(3-Methoxyphenyl)ethylamine with Enantiomerically Pure Mandelica Acid, and the Crystal Structure of Less-Soluble Diastereomeric Salt
Kenichi Sakai*, Yukihiko Hashimoto, Kazushi Kinbara, Kazuhiko Saigo, Hisamichi Murakami, and Hiroyuki Nohira
Bull. Chem. Soc. Jpn. 1993, 66, 3414–3418, DOI: 10.1246/bcsj.66.3414

Optical Resolution and Absolute Configuration of anti Head-to-Head Umbelliferone Dimer
Yutaka Adegawa, Yukihiko Hashimoto, Lan Fang, Masataka Nakamura, Kazushi Kinbara, Masaki Hasegawa, and Kazuhiko Saigo*
Bull. Chem. Soc. Jpn. 1993, 66, 900–905, DOI: 10.1246/bcsj.66.900 

Photoreactive Molecular Complex of 2,5-Distyrylpyrazine and Ethyl 4-[2-(2-Pyrazinyl)ethenyl]cinnamate. Formation of Perfectly Ordered Polymer Composite by Crystalline State Photopolymerization
Masaki Hasegawa*, Kazushi Kinbara, Yutaka Adegawa, and Kazuhiko Saigo*
J. Am. Chem. Soc. 1993, 115, 3820–3821,  DOI: 10.1021/ja00062a076 

総説・解説

総説・解説

Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles
Kohei Sato, Takahiro Muraoka, and Kazushi Kinbara
Accounts of Chemical Research 2021, 54, 3700–3709, DOI: 10.1021/acs.accounts.1c00397  (Selected as “Supplementary Cover)

Introduction: Molecular Motors
Ryota Iino, Kazushi Kinbara*, and Zev Bryant*
Chem. Rev. 2020, 120, 1–4, DOI: 10.1021/acs.chemrev.9b00819 

Session 2SDA—Nonequilibrium energetics of biological molecular machines
Shoichi Toyabe, Chun-Biu Li, and Kazushi Kinbara*
Biophys Rev. 2020, 12, 273–274,  DOI: 10.1007/s12551-020-00634-3 

Monodisperse engineered PEGs for bio-related applications
Kazushi Kinbara*
Polymer Journal, 2018, 50, 689–697, DOI: 10.1038/s41428-018-0074-2

Bioinspired Multi-block Molecules
Takahiro Muraoka and Kazushi Kinbara*
Chem. Commun. 2016, 52, 2667–2678 (Feature Article), DOI: 10.1039/c5cc08052e

Development of Photoresponsive Supramolecular Machines Inspired by Biological Molecular Systems
Takahiro Muraoka, and Kazushi Kinbara*
J. Photoch. Photobio. C 2012, 13, 136–147, DOI: 10.1016/j.jphotochemrev.2012.04.001.

Chiral Ferrocenes as Novel Rotary Modules for Molecular Machines
Kazushi Kinbara*, Takahiro Muraoka, and Takuzo Aida
Org. Biomol. Chem. 2008, 6, 1871–1876, DOI: 10.1039/b718982f [Selected as “Emerging Area” and “Front Cover”; The Top 10 Downloaded Articles in May 2008.]

From Electron Pump to Proton Channel
Kazushi Kinbara and Takuzo Aida
Science 2006, 313, 51–52, DOI: 10.1126/science.113012 

Molecular Pliers Do the Twist
Kazushi Kinbara
The Japan Journal 2006, 9, 29.

Toward Intelligent Molecular Machines: Directed Motions of Biological and Artificial Molecules and Assemblies
Kazushi Kinbara and Takuzo Aida
Chem. Rev. 2005, 105, 1377–1400, DOI: 10.1021/cr030071r 

Design of Resolving Agents Based on Crystal Engineering
Kazushi Kinbara*
Synlett 2005, 5, 732–743, DOI: 10.1055/s-2005-864794

“Kaleidoscopic” Topochemical Photopolymerization Behavior of Diolefin Compounds
Masaki Hasegawa, Chan–Moon Chung, and Kazushi Kinbara
J. Photosci. 1997, 4, 147–160, 1225-8555(pISSN)

EZ-Isomerization of alpha,beta-Unsaturated Acid Derivatives in the Solid State
Kazushi Kinbara, Akiyoshi Kai, Yasunari Maekawa, Yukihiko Hashimoto, Shoji Naruse, Masaki Hasegawa, and Kazuhiko Saigo
Mol. Cryst. Liq. Cryst. 1996, 276, 141–151, DOI: 10.1080/10587259608039371

Molecular-Level Chiral Discrimination and Induction
Kazuhiko Saigo, Yukihiko Hashimoto, Kazushi Kinbara, and Atsushi Sudo
Proc. Indian Acad. Sci. (Chem. Sci.) 1996, 108, 555–573, DOI: 10.1007/BF02896330 

日本語総説・解説

人工イオンチャネル
金原 数
臨床精神薬理 2024, 27(2), 188-189

【座談会】はたらく分子マシン, ナノ世界のエネルギー変換へ
金原 数, 飯野亮太, 竹内正之, 前多裕介,
現代化学 2022, 612, 46-50

化学の本だな 核酸科学ハンドブック
金原 数
化学 2021, 76, 58

はたらく人工イオンチャネル
金原 数
現代化学 2020, 595, 30-33

タンパク質を模倣した人工発動分子の創製に向けて ――膜タンパク質を模倣した合成化学的アプローチ
金原 数
化学と工業  2020, 73, 457-459

物理で理解し, 生物に学び, 化学でつくる!
金原 数
実験医学 2018, 36 (16), 2789

タンパク質はアイデアの宝庫─膜タンパク質を模倣した機能分子の設計
金原 数
現代化学 2014, 516 (3月号), 34-38 

構造化したPEGがタンパク質を熱から守る─タンパク質工学に向けた有機合成化学的アプローチ
金原 数
月刊化学 2013, 68 (11月号), 34-38 

複数回膜貫通型タンパク質の構造模倣と機能開発
村岡貴博、金原 数
有機合成化学協会誌 2013, 71, 1045-1050 

生体分子や分子集合体を接着する「分子糊」
金原 数
高分子, 61(5), 327–331

光で駆動する分子機械
金原 数
光学, 41(2), 78–83 (2012)

光で動く分子機械の開発
金原 数
未来材料, 12 (3月号), 10–14 (2012).

光で駆動する分子機械の設計
金原 数
化学と教育 2011, 59 (4月号), 210–211

生体分子に学ぶ分子機械の設計と機能開拓
金原 数
表面科学 2010, 31 (6月号), 283–289 

分子間で動きを伝える超分子機械の開発
金原 数
有機合成化学協会誌 2009, 67 (10月号), 1044–1052 

化学のブレークスルー【有機化学編】 革新論文から見たこの10年の進歩と未来:「四次元」に向かう分子の進化
金原 数
別冊化学(化学同人) 2009, 43–47 

分子を使って機械を作る 分子ハサミ、分子ペンチへの挑戦
金原 数
未来材料 20088 (12月号), 62-64 

分子レベルで動きを伝達、分子をねじる光駆動分子ペンチ
金原 数
「最新 分子マシン –ナノで動く”高度な機械”を目指して–」(化学同人) 2008, 56–60

半導体ナノ粒子複合体を用いる機能性材料の創成と応用
金原 数
「量子ドットの生命科学領域への応用」(監修: 山本重夫; シーエムシー出版) 2007,  第14章, 159–169 

光で分子を動かす光駆動分子ペンチ
金原 数
光アライアンス 2007,  18 (7月号), 9-13 

分子シャペロンとプレフォールディングを利用したシグナル解析用材料
養王田正文, 金原 数
「一細胞定量解析の最前線 –ライフサーベイヤー構築に向けて–」(監修: 神原秀記, 松永 是, 植田充美; シーエムシー出版) 2006, 第2章–5

分子モーターによるマクロな物質の回転
金原 数
化学, 9月号, 2006, 61-62 

分子を「つまん」で「ねじる」光駆動分子ペンチ
金原 数
バイオニクス, 7月号, 2006, 64-65 

バイオミメティックナノ材料
金原 数,相田卓三
現代化学 2006, 428, 18-22

シャペロニンを利用した動的機能材料
金原 数
高分子 2005, 54, 82

シャペロニンを利用した半導体ナノ粒子の動的制御
金原 数
化学工業 2004, 55, 917-923 

生体分子機械を利用した動的ナノ材料
金原 数
化学と工業, 2004, 57, 923-924

入門ナノテクノロジー 高分子・超分子
金原 数
ぶんせき 2004, 232-239

生体分子機械を用いた新しい動的機能材料
金原 数
Jasco Report 2004, 46, 1-5

シャペロニンを半導体ナノ粒子のキャリアーとして利用する
金原 数, 相田卓三
タンパク質核酸酵素 2004, 49, 857

シャペロニンは分子試験管となり得るのか
金原 数
「生体内の高分子 –機能材料開発と医療への新展開–」(高分子学会) 2003, 第1講, 009–023

シャペロニンによる半導体ナノ粒子の動的制御
金原 数, 相田卓三
Bio Venture 2003, 3 (6), 56-57

キラリティー識別機構の解明と高性能光学分割剤の開発
金原 数, 西郷和彦
科学と工業 2000, 74, 508-514

コングロメレート形成における水素結合の役割
金原 数, 西郷和彦
日本結晶学会誌 1996, 38, 414-420 

紹介された記事

Molecular “Scissors” Work in Response to Light
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Coupled Mechanical Motion in a Molecular Machine
Foresight Nanotech Update, 57/ Winter Issue, 15 (2006).

Intermolecular Coupling of Motion under Photochemical Control
Raymo, F. M.
Angew. Chem. Int. Ed., 45, 5249–5251 (2006).

Molecular Pas De Deux, Photoreactive Host Molecule Mechanically Twists Guest Compound
Chemical & Engineering News, 84, 9 (2006).

Molecular Machine Twists Other Molecules
Nanotechweb.org, March 22, 2006.

First Molecular-Machine Combination Revealed
NewScientist, March 22, 2006.

Borrowing from Biology
Nature, June 5, 2003.

Quantum Dot Advances
Chemical & Engineering News, 81, 10 (2003).

Protein Traps Nanoparticles
TRNmag.com, June 18, 2003.

Bacterial Proteins Coat Nanoparticles for Bioresponsivity
Nanotechweb.org, June 4, 2003.

Molecular Scissors Make Their Point
NewScientist, May 31, 2003.